Ncor1 ELISA Kit for Mouse(Mus musculus) | EIAab.comNcor1 ELISA Kit for Mouse(Mus musculus)

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Ncor1 (Gene name),

Nuclear receptor corepressor 1 (Protein name ), NCOR1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ncor1(Rxrip13);

Protein name:

Nuclear receptor corepressor 1(N-CoR;N-CoR1);

Alternative:

Retinoid X receptor-interacting protein 13(RIP13);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with HEXIM1 (By similarity). Interacts with C1D, SIAH2, HDAC7, SAP30, SIN3A and SIN3B. Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2.

Function:

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

2453

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SDD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q60974

UniGene:

Mm.271814

Pfam:

PF00249

SMR:

Q60974

Uniprot:

Q60974

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ELISA Kit for Mouse N-CoR

Cat.:

E0349h

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96T

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ELISA Kit for Mouse N-CoR

Cat.:

E0349m

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96T

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ELISA Kit for Mouse N-CoR

Cat.:

E0349r

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96T

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CLIA Kit for Mouse N-CoR

Cat.:

U0349r

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Packing:

96T

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CLIA Kit for Mouse N-CoR

Cat.:

U0349m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse N-CoR

Cat.:

U0349h

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Looking for manual.

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Packing:

96T

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Polyclonal Antibody for Mouse N-CoR

Cat.:

P0349Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse N-CoR

Cat.:

P0349Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse N-CoR

Cat.:

P0349Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse N-CoR

Protein for Mouse N-CoR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor."
Hoerlein A.J. , Naeaer A.M. , Heinzel T. , Torchia J. , Gloss B. , Kurokawa R. , Ryan A. , Kamei Y. , Soederstroem M. , Glass C.K. , Rosenfeld M.G.
Nature377:397-404(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue: Pituitary.
2.

"Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors."
Seol W. , Choi H.S. , Moore D.D.
Mol. Endocrinol.9:72-85(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1792-2453 (ISOFORM 1)
tissue: Liver.
3.

"Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR."
Seol W. , Mahon M.J. , Lee Y.-K. , Moore D.D.
Mol. Endocrinol.10:1646-1655(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RARB; RXRA AND THRB;DOMAINS ID1 AND ID2
4.

"A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression."
Heinzel T. , Lavinsky R.M. , Mullen T.-M. , Soederstroem M. , Laherty C.D. , Torchia J. , Yang W.M. , Brard G. , Ngo S.D. , Davie J.R. , Seto E. , Eisenman R.N. , Rose D.W. , Glass C.K. , Rosenfeld M.G.
Nature387:43-48(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIN3A AND SIN3B
5.

"Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
Zamir I. , Dawson J. , Lavinsky R.M. , Glass C.K. , Rosenfeld M.G. , Lazar M.A.
Proc. Natl. Acad. Sci. U.S.A.94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C1D
6.

"Proteasomal regulation of nuclear receptor corepressor-mediated repression."
Zhang J. , Guenther M.G. , Carthew R.W. , Lazar M.A.
Genes Dev.12:1775-1780(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIAH2;DEGRADATION
7.

"SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors."
Laherty C.D. , Billin A.N. , Lavinsky R.M. , Yochum G.S. , Bush A.C. , Sun J.-M. , Mullen T.-M. , Davie J.R. , Rose D.W. , Glass C.K. , Rosenfeld M.G. , Ayer D.E. , Eisenman R.N.
Mol. Cell2:33-42(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SAP30 AND SIN3A
8.

"Identification of a nuclear domain with deacetylase activity."
Downes M. , Ordentlich P. , Kao H.-Y. , Alvarez J.G.A. , Evans R.M.
Proc. Natl. Acad. Sci. U.S.A.97:10330-10335(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC7
9.

"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
Amann J.M. , Nip J. , Strom D.K. , Lutterbach B. , Harada H. , Lenny N. , Downing J.R. , Meyers S. , Hiebert S.W.
Mol. Cell. Biol.21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBFA2T3
10.

"Tissue-specific regulation of retinal and pituitary precursor cell proliferation."
Li X. , Perissi V. , Liu F. , Rose D.W. , Rosenfeld M.G.
Science297:1180-1183(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DACH1
11.

"Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function."
Huq M.D. , Tsai N.-P. , Khan S.A. , Wei L.-N.
Mol. Cell. Proteomics6:677-688(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RARA
12.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1481; SER-2449 AND SER-2451;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
13.

"A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters."
Bruck N. , Vitoux D. , Ferry C. , Duong V. , Bauer A. , de The H. , Rochette-Egly C.
EMBO J.28:34-47(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RARA
14.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224 AND SER-1481;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2198;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
16.

"The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors."
Cho Y. , Noshiro M. , Choi M. , Morita K. , Kawamoto T. , Fujimoto K. , Kato Y. , Makishima M.
Mol. Pharmacol.76:1360-1369(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RXRA
17.

"Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand."
Solt L.A. , Kumar N. , Nuhant P. , Wang Y. , Lauer J.L. , Liu J. , Istrate M.A. , Kamenecka T.M. , Roush W.R. , Vidovic D. , Schuerer S.C. , Xu J. , Wagoner G. , Drew P.D. , Griffin P.R. , Burris T.P.
Nature472:491-494(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RORA AND RORC
18.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1347;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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